Download PDF by Haboush W., Parshall B. (eds.): Algebraic Groups and Their Generalizations: Classical

By Haboush W., Parshall B. (eds.)

ISBN-10: 0821814974

ISBN-13: 9780821814970

ISBN-10: 0821815407

ISBN-13: 9780821815403

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ISBN-13: 9780821815410

ISBN-10: 1481858173

ISBN-13: 9781481858175

ISBN-10: 2919781782

ISBN-13: 9782919781782

ISBN-10: 4219871071

ISBN-13: 9784219871071

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Blood 110:3281–3290 120. Parlati F, Lee SJ, Aujay M, Suzuki E, Levitsky K, Lorens JB, Micklem DR, Ruurs P, Sylvain C, Lu Y, Shenk KD, Bennett MK (2009) Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome. Blood 114:3439–3447 121. Demo SD, Kirk CJ, Aujay MA, Buchholz TJ, Dajee M, Ho MN, Jiang J, Laidig GJ, Lewis ER, Parlati F, Shenk KD, Smyth MS, Sun CM, Vallone MK, Woo TM, Molineaux CJ, Bennett MK (2007) Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome.

M. Schmitt et al. 3 Immunoproteasome-Specific Inhibitors The immunoproteasome is an inducible proteasome variant primarily expressed in lymphocytes and monocytes, as well as in cells exposed to inflammatory cytokines such as interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α). The immunoproteasome is involved in the production of peptides for major histocompatibility complex-­1 (MHC-1). During assembly of the immunoproteasome, the constitutive β1, β2, and β5 subunits are replaced by β1i (PSMB9/LMP2), β2i (PSMB10/LMP-10/ MECL1), and β5i (PSMB8/LMP7), respectively.

Cancer 107:2688–2697 64. Ryan DP, Appleman LJ, Lynch T, Supko JG, Fidias P, Clark JW, Fishman M, Zhu AX, Enzinger PC, Kashala O, Cusack J Jr, Eder JP (2006) Phase I clinical trial of bortezomib in combination with gemcitabine in patients with advanced solid tumors. Cancer 107:2482–2489 65. Nix D, Milton M, Pligavko C, et al (2003) Pharmacokinetics of the proteasome inhibitor bortezomib (Velcade) in male cynomolgus monkeys (abstract C245). AACR-NCI-EORTC molecular targets and cancer therapeutics discovery, biology, and clinical applications meeting 66.

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Algebraic Groups and Their Generalizations: Classical Methods, Part 1 by Haboush W., Parshall B. (eds.)

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