Download e-book for iPad: An Engineering Introduction to Biotechnology by J. Patrick Fitch

By J. Patrick Fitch

ISBN-10: 0819444979

ISBN-13: 9780819444974

This instructional may also help technical execs in optics make certain even if their applied sciences have capability software within the existence sciences. It is also precious as a ''prep class'' for extra specific books on biology and biotechnology, filling the distance among basic and high-level approaches.

Contents

- Preface
- uncomplicated Biology
- Nucleic Acids because the Blueprint
- Manipulating Nucleic Acids and Proteins
- An built-in technique for organic Discovery
- DNA Sequencing
- Detecting Nucleic Acids
- Protein Structure
- Appendix A: devices and Measures
- Appendix B: Nonscientific Issues
- suggested Reading
- Index

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Sample text

10. (a) Chemical schematic of an amino acid showing the carboxyl group, amino group, hydrogen atom, alpha carbon, and residue R. (b) Chain of amino acids connected via peptide bonds. 1. The 64 three-base codons (5′ to 3′ DNA) with the corresponding mRNA (5′ to 3′ mRNA) and the 20 amino acids. The single letter abbreviations are only used in long lists. Note that the DNA corresponds to the 5′ to 3′ gene and so the mRNA bases are identical with the T-to-U substitution. The mRNA is the complement of the 3′ to 5′ DNA strand that participates in mRNA transcription.

2. The last 7 of 629 amino acids in the dystrophia myotonica protein kinase (DMPK) and the associated DNA bases in the gene. Position 623 624 625 626 627 628 629 P G A A R A P Letter Gly Ala Ala Arg Ala Pro Abbrev. Pro Acid Proline Glycine Alanine Alanine Arginine Alanine Proline GCA GCC GCC CGC GCU CCC mRNA CCA GGA GCC GCC CGC GCT CCC DNA CCA The gene associated with myotonic dystrophy was discovered as part of research being conducted on the disease. The MD approach of using disease markers to find the associated DNA regions and then sequence those specific regions represents the approach of the 1980s and early 1990s.

5). Chromosomes are made of repeating nucleosome subunits. a) b) Fig. 4. Familiar double helix structure of DNA or twisted ladder with a sugarphosphate backbone and nitrogenous base rungs. The a) “licorice and ribbons” and b) space-filled views of the Drew-Dickerson dodecamer, the first highresolution measured crystal structure of B-DNA. B-DNA is the dominant form of DNA under physiological conditions. 5 nm DNA Fig. 5. The DNA-histone package that makes up chromosomes is called a nucleosome. Chromosomes are about 50% protein (usually histone) and 50% DNA.

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An Engineering Introduction to Biotechnology by J. Patrick Fitch


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